Particle Size Distribution and yield control in continuous Plug Flow Crystallizers with recycle
نویسندگان
چکیده
منابع مشابه
Crystal Engineering in Continuous Plug-Flow Crystallizers
Size, shape, and polymorphic form are the critical attributes of crystalline particles and represent the major focus of today's crystallization process design. This work demonstrates how crystal properties can be tuned efficiently in solution via a tubular crystallizer that facilitates rapid temperature cycling. Controlled crystal growth, dissolution, and secondary nucleation allow a precise co...
متن کاملDesign and Optimization of Plug Flow Crystallizers
This study presents the development of a plug flow crystallization (PFC) platform consisting of a vortex mixer combined with a tubular reactor. Process analytical technologies (FBRM, PVM, FT-IR) were applied in-situ in order to characterize and optimize crystallizations via the use of novel flow cells. In addition to this a new calibration free method for concentration monitoring was successful...
متن کاملWhat is a Continuous Particle Size Distribution ?
Differential Distribution: The differential distribution shows the relative amount* at each size. For example, for the one shown here, using a ruler to draw horizontal and vertical lines, one can determine that the differential amount at 14.5 nm is about 40 while at 18 nm it is about 20. Therefore, the differential distribution is telling us there is twice the amount at 14.5 nm compared to the ...
متن کاملPrecise tailoring of the crystal size distribution by controlled growth and continuous seeding from impinging jet crystallizers
The desired bioavailability and the method of drug administration and delivery can require stringent control on the crystal size distribution. Optimal control strategies are proposed to manufacture crystals with a targeted size distribution by combining controlled seeding by impinging jet crystallization with a batch crystallizer operating at a controlled constant growth rate. The same strategi...
متن کاملPredictions of gas r particle flow with an Eulerian model including a realistic particle size distribution
This paper presents a computational study of the flow behavior in a cold-flow pilot-scale circulating fluidized bed. A multi-fluid Ž . Computational Fluid Dynamics CFD model has been developed and verified against experimental data reported in the literature. The flow model is based on an Eulerian description of the phases where the kinetic theory of granular flow forms the basis for the turbul...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical Engineering Science
سال: 2015
ISSN: 0009-2509
DOI: 10.1016/j.ces.2015.08.041